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“The Exercise Pill” Nov. 6, 2017

The New Yorker

In her exploration of the biology and chemistry of physical exercise, Nicola Twilley introduces the reader to Couch Potato Mouse and Lance Armstrong Mouse. Both had been fed a diet consisting almost entirely of fat and sugar and got little exercise. But while Couch Potato Mouse was lethargic, with rolls of visible fat, Lance Armstrong Mouse was lean, taut and active in its cage. It had been fed a daily dose of GW501516 or “516”, a drug that, as Twilley puts it, “confers beneficial effects of exercise without the need to move a muscle.” Whether such drugs will ever prove beneficial for...Read more